月薪38388元 台北市南港區 工作經歷不拘 1天前
※工作內容:
The Tsai laboratory is looking for highly motivated talents to help us unveil how RNA modifications impact RNA biology. Successful applicants may aid in the following potential projects:
- Elucidate how intracellular Adenosine metabolism may regulate RNA methylation rates, in turn impacting Neurodegeneration in Alzheimer‘s disease model systems, in a collaboration with Yijuang Chern, Yi-Shuian Huang and others. This project involve the development and adaptation of new RNA modification detection methods, which may utilize the latest in Nanopore direct RNA-seq, Illumina RNA-seq, UPLC-tandem mass spectrometry, as well as more traditional molecular biology techniques.
- Explore how RNA modifications on viral and small RNAs in mosquito and monkey samples may impact the zoonotic virus reservoir within these animals that may spread to humans, in collaboration with Shin-Ru Shih. This project mainly utilizes Nanopore direct RNA-seq, though may not be limited to this technique.
- Elucidate how RNA modifications facilitate the replication, gene expression, and antiviral factor avoidance of Hepatitis B virus. This is a curiosity driven project that is not tied to any specific technique.
- General Nanopore direct RNA-seq bioinformatics analysis in support of any of the above projects.
蔡松智實驗室徵求具高度研究熱忱的優秀人才,共同探索RNA小分子修飾(如甲基化)如何影響RNA功能。可能的研究計畫包含:
- 細胞內Adenosine濃度對RNA甲基化的影響,而此機制如何影響阿茲海默症相關的神經退化:本計畫為與陳儀莊、黃怡萱老師及相關團隊之合作計畫。研究內容包含開發與優化最新的RNA修飾檢測技術,可能採用 Nanopore direct RNA-seq、Illumina RNA定序、超高效液相層析串聯質譜儀(UPLC-MS/MS)以及傳統分子生物學技術。
- 蚊子與猴子樣本中病毒及small RNA 修飾之研究: 本計畫與施信如老師合作,探討 RNA 修飾如何影響這些動物宿主體內的人畜共通病毒以及其向人類傳播的潛力。研究技術以 Nanopore direct RNA-seq為主。
- B型肝炎病毒(HBV)之 RNA 修飾: 釐清 RNA修飾如何協助B型肝炎病毒的複製、基因表現與逃避抗病毒因子之機制。此計畫所需技術依實驗結果而定不限於特定實驗技術。
- 針對Nanopore direct RNA-seq之生物資訊分析(可能協助以上所有計畫)。
※應徵資格:
生物學系/生化科技/醫學科系/醫事檢驗/資訊工程/程式設計 等相關科系大學/碩士畢業,英文中等。
We are looking for candidates of all levels including research assistants, post docs and graduate students, with biology, medicine or computer-related backgrounds. Preferred candidates should be active problem solvers, either though asking collages, reading papers, or designing experiments to obtain answers. Taipei is a great city for specialty coffee lovers and outdoor activity enthusiasts. The PI is Taiwanese-American and welcomes talents of all nationalities as long as the candidate can communicate in English. Research assistants applicants who wish to transition to a graduate program abroad in 2-3 years are welcome.
徵求碩士級助理,生物醫學或資訊相關背景。
應徵者希望是對病毒或RNA有興趣,並樂於解決問題的人。
歡迎有志在本實驗室準備2-3年後出國的研究助理。需有基本的英文溝通與閱讀能力。研究需要常保腦活,因此希望實驗室成員能夠在不過勞的生活型態下保有生產力。
台北四周環山,城郊自然活動場域豐富而易達;城裡有多重精品咖啡選擇,歡迎同好加入。薪資以中研院標準為基準,可依專長與所需工作之契合度加給。
※工作待遇:
依中研院薪資標準––學士級NT$38,388元起薪,碩士級NT$44,968元起薪。
※應徵方式:
Please contact Kevin Tsai at kevtsai@ibms.sinica.edu.tw with your CV, cover letter and 2-3 references to discuss opportunities. Please note that only applicants who are invited for an interview will be contacted.
有意者請把履歷(CV)和推薦信(或2-3位推薦人聯絡資料)寄到kevtsai@ibms.sinica.edu.tw 並在信中簡短推銷自己。恕僅回覆有意面試者。
※應徵注意事項:
希望加入我們修習博士班的有志之士煩請申請中研院台灣國際研究生學程 (TIGP, 請見 https://tigp.sinica.edu.tw/MM.html )
有興趣加入我們修習碩士班者煩請申請台大醫學院微生物所 (https://www.mc.ntu.edu.tw/micro/Fpage.action?muid=7&fid=745)
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